to The Intravenous Amiodarone Source (Amiodarone IV), an interactive Internet
site intended for US audiences. This web site is designed for physicians
and other healthcare personnel who want information on important and new
aspects of Amiodarone IV (Cordarone IV®).
Amiodarone IV has important applications as an intravenous antiarrhythmic drug because of efficacy, safety, and a broad spectrum of activity. The ARREST study (New Engl J Med; 341:871-8, 1999) reported that in patients with out-of-hospital cardiac arrest due to refractory ventricular arrhythmias, treatment with amiodarone IV resulted in a higher rate of survival to hospital admission. With the ongoing research in resuscitation, the American Heart Association has reviewed the scientific and other supporting data to revise the guidelines for Advanced Cardiopulmonary Life Support (ACLS). Amiodarone IV is now the first choice antiarrhythmic for persistent ventricular fibrillation or pulseless ventricular tachycardia (American Heart Association. Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2000;102(suppl): I-86-I-166).
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